PELNAC Gplus™

Collagen-based artificial dermis containing alkaline treated gelatin

Features

PELNAC Gplus is a two-layered collagen-based artificial dermis. It consists of a collagen-sponge containing alkaline treated gelatin and a silicone film which functions as a scaffold for dermal regeneration. It also comes in the following variations: single-layer-type without the silicone film and fenestrated-type with drain slits in both layers.
When applying this product to full-thickness skin defects, capillaries and fibroblasts infiltrate into the collagen-sponge and serve as a matrix for the regeneration of dermis-like tissue.

PELNAC Gplus is currently only available in Japan.

References

  • Jinno C, Morimoto N, Ito R, Sakamoto M, Ogino S, Taira T, Suzuki S. A Comparison of Conventional Collagen Sponge and Collagen-Gelatin Sponge in Wound Healing. BioMed Research International Volume 2016, Article ID 4567146, 8 pages.
  • Morimoto N, Yoshimura K, Niimi M, Ito T, Aya R, Fujitaka J. Tada H, Teramukai S, Murayama T, Toyooka C, Miura K, Takemoto S, Kanda N, Kawai K, Yokode M, Shimizu A, Suzuki S. Novel collagen/gelatin scaffold with sustained release of basic fibroblast growth factor: clinical trial for chronic skin ulcers. Tissue Engineering Part A. 2013; 19(17-18): 1931-1940
  • Ito R, Morimoto N, Pham L.H, Taira T, Kawai K, Suzuki, S. Efficacy of the Controlled Release of Concentrated Platelet Lysate from a Collagen/Gelatin Scaffold for Dermis-Like Tissue Regeneration. Tissue Engineering Part A. 2019; 19 (11-12):1398-1405
  • Ogino S, Morimoto N, Sakamoto M, Jinno C, Sakamoto Y, Taira T, Suzuki S. Efficacy of the dual controlled release of HGF and bFGF impregnated with a collagen/gelatin scaffold. Journal of surgical research. 2018; 221:173-182
  • Matsumine H, Fujimaki H, Takagi M, Mori S, Iwata T, Shimizu M, Takeuchi M. Full-thickness skin reconstruction with basic fibroblast growth factor-impregnated collagen-gelatin sponge.
    Regenerative Therapy. 2019; 11: 81-87
  • Notodihardjo S.C, Morimoto N, Munisso M.C, Le T.M, Mitsui T, Kakudo N, Kusumoto K. A comparison of the wound healing process after the application of three dermal substitutes with or without basic fibroblast growth factor impregnation in diabetic mice. Journal of Plastic, Reconstructive and Aesthetic Surgery. 2020; 73(8): 1547-1555