Collagen-based artificial dermis

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PELNAC is made of an atelocollagen sponge layer, which provides the scaffold for dermal regeneration, and a silicone film layer, which can prevent external infection and moisture control.
When used to treat damaged or defective dermal layers, fibroblasts and capillaries infiltrate the collagen matrix, which is replaced with dermis-like tissue after 2-3 weeks.
It is indicated for use in deep burns, exposed bone, or other full-thickness skin defect wounds. Using PELNAC may possibly lead to excellent functional and aesthetic results thanks to less contracture after surgery.



  • Maruccia M, Marannino P.C, Elia R, Ribatti D, Tamma R, Nacchiero E, Manrique J.O, Giudice G. Treatment of finger degloving injury with acellular dermal matrices: Functional and aesthetic results. Journal of Plastic, Reconstructive & Aesthetic Surgery. 2019; 72(9): 1509-1517
  • Widjaja W, Maitz P. The use of dermal regeneration tamplate (Pelnac) in acute full-thickness wound closure: A case series. European Jounal of Plastic Surgery. 2016; 39: 125-132
  • Scuderi N, Fioramonti P, Fanelli B, Fino P, Spalvieri C. The use of dermal regeneration template (Pelnac) in a complex upper limp trauma: the first Italian case report. European Review for Medical and Pharmacological Science. 2019; 23: 5531-5534
  • Morimoto N, Kuro A, Yamauchi T, Horiuchi A, Kakudo N, Sakamoto M, Suzuki K, Kusumoto K. Combined use of fenestrated-type artificial dermis and topical negative pressure wound therapy for the venous leg ulcer of a rheumatoid arthritis patient. International wound journal. 2016; 13 (1): 137-140
  • Sallustro M, Polichetti R, Florio A. Use of Porcine-Derived Dermal Substitutes for Treatment of Nonhealing Vascular Leg Ulcers: A Case Series. The International Journal of Lower Extremity Wounds. 2020